Weight Loss

How do GLP-1 medications work for weight loss?

GLP-1 (glucagon-like peptide-1) receptor agonists help people lose weight in two key ways:

1. Delayed gastric emptying – food leaves the stomach more slowly, so you feel full longer.
2. Appetite signaling – GLP-1 sends “still satisfied” messages to the brain, lowering hunger and cravings.

How much weight can I lose with a GLP-1 medication?

In large, placebo-controlled trials of weekly GLP-1 injections, participants lost about 12–15 percent of their starting body weight over 12–18 months. In everyday practice, our patients commonly lose 4–6 lbs per month, with some dropping more than 15 lbs in the first month.

Are GLP-1 injectables FDA-approved for weight control?

Yes. Several GLP-1 receptor agonists are FDA-approved for chronic weight management in adults with a BMI ≥ 30 kg/m² (or ≥ 27 kg/m² with a weight-related condition). Clinical studies consistently show double-digit percentage weight reductions compared with placebo.

Getting the best results on a GLP-1 program

Medication works best when paired with a balanced, reduced-calorie diet, regular physical activity, and a strong support system. These lifestyle measures help maintain the weight you lose and improve overall metabolic health.

Dosing schedule

Most GLP-1 weight-loss injectables are taken once weekly. Your provider will usually start at a low dose and increase gradually as tolerated to minimize side-effects.

Effects on blood sugar

Because GLP-1 agonists were originally developed for type 2 diabetes, many people see steadier blood-glucose levels while on therapy. Low blood sugar is rare unless you also use insulin or sulfonylureas—always tell your clinician about every medication and supplement you take.

How to take the injection

You’ll be shown how to self-inject subcutaneously in the arm, thigh, or abdomen. Start low, go slow: doses are typically increased every four weeks while you stay hydrated and monitor for temporary effects such as nausea, constipation, or headache.

Weight Loss FAQ’s

Common side-effects

The most frequently reported effects are nausea, vomiting, diarrhea, constipation, bloating, and mild headache (occasional burping, too). We offer a gentler, BPC-157-enhanced formulation for patients with sensitive stomachs. Rare but serious reactions include rash, swelling, or trouble swallowing—seek medical attention right away if these occur. Magnesium supplements can help ease constipation for some people.

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Who should avoid GLP-1 therapy?

Do not start a GLP-1 program if you are:

• Pregnant, trying to conceive, or breastfeeding
• On dialysis or have severe kidney disease
• Living with a history of medullary thyroid cancer, pancreatitis, or gastroparesis

Discuss any past bariatric surgery, gallbladder disease, cardiovascular conditions, or other concerns with your provider first.

Labs and baseline measurements

Before your first injection, we order a complete blood count and basic metabolic panel, check inflammatory markers where appropriate, and record your starting weight and blood pressure.

What will I feel while taking a weekly GLP-1?

Most people notice a diminished appetite, steady energy, and gradual improvement in blood-pressure or cholesterol numbers as the pounds drop. Average weight-loss hovers around 15 percent of baseline when medication, diet, and exercise all work together.

Follow-up schedule

In our Scottsdale clinic we see patients monthly during dose titration to track progress, blood pressure, and any side-effects. Once you reach a stable maintenance dose, visits become less frequent.

Can I stop once I hit my goal weight?

Yes. You and your clinician can taper or discontinue the medication once you’re confident the new habits will hold. Most people transition off without rebound nausea; ongoing lifestyle practices remain crucial for maintaining results.

Will I regain weight afterward?

Weight rebound is uncommon when patients keep monthly check-ins, maintain a reduced-calorie diet, and stay active. GLP-1 therapy has been a game-changer for long-term weight management—contact our Scottsdale team to see if it’s right for your journey.